Scientist 'G', National Centre for Cell Science (NCCS),
NCCS Complex, Pune University Campus, Ganeshkhind , Pune - 411 007, India.
Dr. Mrs. Vaijayanti P. Kale obtained Ph.D. degree from theUniversityofMumbai,India(1985) and received post-doctoral training in mycobacterial immunology at CDC/MSM,Atlanta,USA(1985-86). After working as a research officer on an ICMR-funded project on anti-leprosy vaccine at Tata Cancer Research Centre, Mumbai for two years (1986-88) and for one year on BSK-funded project at JJ Hospital, Mumbai, she joined as a scientist in the National Centre for Cell Science (NCCS) in 1989. Here she initiated the research program on hematopoietic stem cells isolated from human bone marrow with a special focus the mechanisms involved in the regulation of stem cell fate via the microenvironment or niche.
She has developed an in vitro culture system, Artificial Bone Marrow-like microenvironments (ABME) that can be used to augment the stem cell functions. An international patent has been filed on this system and is being defended in several countries (granted inNew Zealand,Singapore,AustraliaandIndia). This technology has an immense translational potential and patients undergoing stem cell therapy or suffering from bone marrow failure syndromes may benefit from its application.
She has also developed a hydrogel-based three dimensional culture of mesenchymal stem cells that mimics the in vivo HSC-niche (Sharma et al 2011 Haematologica). This 3D system is an excellent model to study niche-mediated regulation of stem cells, not only in the context of hematopoietic stem cells but also for other tissue-specific stem cells as well.
She has received several extra-mural grants from funding agencies like DBT, DST, BRNS etc. Recently she has initiated a large program involving development of mesenchymal stem cells expressing hematopoiesis- supportive genes and studying their effect on the HSC fate in a co-culture model. She has also initiated a program on Diabetes-induced EPC dysfunction and its rescue by using Curcumin.
Dr. Kale has several publications in international peer reviewed journals to her credit. She is a member of ICMR task force on stem cell research and therapy. She has been appointed as an associate editor of international journals namely Stem cells and Development, Biomedical Research Journal, InSciences Journal and Annals of Neurobiology. She is also an active member of international and national research organizations like International Society of Experimental Hematology, International Society for Stem Cell Research, Indian Society of Cell Biology, Indian Society of Biotechnology and Indian Society of Microbiologists. She also serves on several ethical committees as stem cell expert.
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